Olinvyk oliceridine fumarate – 1 mg/mL ,30 milliliters , Solution

Increased risk of hypotension, respiratory depression, sedation, coma, death with benzodiazepines or other CNS depressants (eg, non-benzodiazepine sedatives/hypnotics, anxiolytics, general anesthetics, phenothiazines, tranquilizers, muscle relaxants, antipsychotics, alcohol, other opioids); reserve concomitant use in those for whom alternative options are inadequate; limit dosages/durations to minimum required; monitor. May be potentiated by moderate to strong CYP3A4 inhibitors (eg, macrolides, azole antifungals, SSRIs, protease or NS3/4A inhibitors), moderate to strong CYP2D6 inhibitors (eg, paroxetine, fluoxetine, quinidine, bupropion); monitor. May be antagonized by CYP3A4 inducers (eg, rifampin, carbamazepine, phenytoin); monitor. Risk of serotonin syndrome with serotonergic drugs (eg, SSRIs, SNRIs, TCAs, triptans, 5-HT₃antagonists, mirtazapine, trazodone, tramadol, cyclobenzaprine, metaxalone, MAOIs, linezolid, IV methylene blue); monitor and discontinue if suspected. Avoid concomitant mixed agonist/antagonist opioids (eg, butorphanol, nalbuphine, pentazocine) or partial agonist (eg, buprenorphine); may reduce effects and/or precipitate withdrawal symptoms. Potentiates muscle relaxants; monitor. May antagonize diuretics; monitor. Paralytic ileus may occur with anticholinergics.